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friday :: may 6, 2005
biology of gender: defining male and female

Gender, often said to depend solely upon anatomy or hormones, may depend also on hard-wired genetics, according to new research that could help doctors and lawyers better understand the one in 4,000 babies born with both male and female traits.

"The biology of gender is far more complicated than XX or XY chromosomes and may rely more on the brain's very early development than we ever imagined," researcher Eric Vilain, M.D., reported.

"Surgical sex assignment of newborns with no capacity to consent should never be performed for cosmetic reasons, in my opinion," said Vilain, an associate professor of human genetics who also serves as a chief of medical genetics and director of research in urology and sexual medicine within the David Geffen School of Medicine at the University of California, Los Angeles. "We simply don't know enough yet about gender to be making surgical or legal assumptions."

William G. Reiner, M.D., agreed. "The most important sex organ is the brain," said Reiner, a psychiatrist and associate professor in the Department of Urology, Oklahoma University Health Science Center. "We have to let these children tell us their gender at the appropriate time."

An estimated 1 in 4,000 to 1 in 5,000 babies may be classified as "gender ambiguous" because intersex conditions affecting their genitalia, reproductive systems or sex chromosomes make an immediate assessment impossible, Reiner explained.

Yet, many laws -- including U.S. marriage laws -- assume that everyone is clearly male or female, a concept known in legal circles as sexual dimorphism, or binary law, legal expert Susan Becker of the Cleveland State University explained. At the same time, children with ambiguous genitalia continue to undergo surgical sex assignment. >from *Defining male and female*. Research casts further doubt on newborn sex-assignment surgeries. February 18, 2005

related context
studies expand understanding of x chromosome. new insights into the evolution of sex chromosomes and the biological differences between males and females. march 16, 2005
> intelligence in men and women. february 4, 2005
> everything you always wanted to know about sexes. june, 2004
> sex in the brain. february 17, 2004
> neurobiological basis of romantic love. november 26, 2003
> conflict interaction of couples. october 27, 2003
> biodiversity include sexual diversity: extended concept of biodiversity. june 14, 2002

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